CN · Field Sheet
FIELD SHEET — ST. JOHN'S WORT MFI-STJOHN-20261023-FS
Survey index / ST. JOHN'S WORT

St. John's Wort.

Hypericum perforatum
Hypericum herb; mood-disorder evidence and interaction profile.
SEALED MFI-STJOHN-20261023-FS · RELEASED 2026-10-23
SHEET FINGERPRINTMFI-STJOHN-20261023-FS
318INCLUDED
1,935EXCLUDED
50DUPLICATE
52NON-TRANSFERABLE
2OUT OF CUTOFF
Survey totalsScroll ↓
2,357records surveyed
318studies
26claims graded
115observations
7,948graph nodes

Claim records

2 shown · bounded preview
RECORD PREVIEW · FIELD RECORD ×2BOUNDED — REAL RELEASED DATA
CLAIM · CLM-888deeb2df8a56a2GRADE VERY_LOW
st. john's wort constituents — mood
direction BENEFIT · dose 600 mg · duration 10 days; 42 day; 6 week
Grade basis — weakest-link ceilings
MODERATEdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
7bound studies
Bound studies (4 shown of 7)
STU-121afd32df75e7a5
ANIMAL · ANIMAL · 2024 · RoB INSUFFICIENT_INFORMATION
2 endpoints
STU-46024a914ede8180
RCT · HUMAN · 2011 · RoB SOME_CONCERNS
1 endpoints
STU-46904161dc1004cf
ANIMAL · ANIMAL · 2020 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-555a10c5b1d4f11e
ANIMAL · ANIMAL · 2025 · 10 days · RoB INSUFFICIENT_INFORMATION
2 endpoints
Quantitative observations
observation 6 week · failed extraction
observation 1300 · validated
observation 42 day · failed extraction
Opposition screen
SCREEN · 17 candidates considered · 3 bound as opposing
SYNTHESIS SYN-6ad85f2db0466a — outcome QUALITATIVE_ONLY · BENEFIT ×7 · not_assessed_quantitatively · 7 members
PROVENANCE → epmc:39684380, epmc:23964473, epmc:33628177 · PKG 7f8e2515f10fdabf…
CLAIM · CLM-d9ebee1bb723db3bGRADE VERY_LOW
st. john's wort constituents — inflammation
direction UNCERTAIN · dose UNSPECIFIED · duration 7 days
Grade basis — weakest-link ceilings
VERY_LOWdesign
LOWdirectness
MODERATEextraction
LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
7bound studies
Bound studies (4 shown of 7)
STU-423e75c88e033dfe
ANIMAL · ANIMAL · 2026 · 7 days · RoB INSUFFICIENT_INFORMATION
2 endpoints
STU-46904161dc1004cf
ANIMAL · ANIMAL · 2020 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-6f5dabd9ec999075
ANIMAL · ANIMAL · 2017 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-86ca3efd8c1ea7f8
ANIMAL · ANIMAL · 2019 · RoB INSUFFICIENT_INFORMATION
2 endpoints
Quantitative observations
observation 7 days · failed extraction
observation p < 0.05 · validated
observation lowered the glutamate-induced cytotoxicity by 13.2% · failed extraction
Opposition screen
SCREEN · 7 candidates considered · 3 bound as opposing
SYNTHESIS SYN-3afed9c49d3579 — outcome QUALITATIVE_ONLY · BENEFIT ×2 · HARM ×2 · UNCERTAIN ×3 · directional_disagreement · 7 members
PROVENANCE → epmc:41766189, epmc:33628177, epmc:29279803 · PKG 7f8e2515f10fdabf…
Bounded preview — representative records only. The full release ships 26 claims and 115 observations.