RECORD PREVIEW · FIELD RECORD ×2BOUNDED — REAL RELEASED DATA
CLAIM · CLM-1dc1efb1d5118072GRADE VERY_LOW
psilocybin — mood
direction BENEFIT · dose 0.17 mg/kg; 0.32 mg/kg; 0.88 mg/kg; 25 mg; 30 mg; 4.4 mg/kg; 5 mg · duration 16 weeks; 21 days
Grade basis — weakest-link ceilings
HIGHdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
LOWmethodology
MODERATEconsistency
MODERATEnumeric
23bound studies
Bound studies (4 shown of 23)
STU-144b3da5e1cfc5adANIMAL · ANIMAL · 2023 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-196a555812675bd5RCT · HUMAN · 2025 · RoB SOME_CONCERNS
1 endpoints
STU-1f1562a5755657beRCT · HUMAN · 2025 · RoB SOME_CONCERNS
2 endpoints
STU-3e0f40cb1ac7527cRCT · HUMAN · 2026 · RoB INSUFFICIENT_INFORMATION
1 endpoints
Quantitative observations
observation p < 0.001 · validated
observation 16 weeks · failed extraction
observation 5 · validated
Opposition screen
SCREEN · 45 candidates considered · 3 bound as opposing
SYNTHESIS SYN-f961a7650498fe — outcome QUALITATIVE_ONLY · BENEFIT ×23 · not_assessed_quantitatively · 23 members
PROVENANCE → epmc:36985596, epmc:39973494, epmc:40858059 · PKG 90925e4e59c27627…
CLAIM · CLM-a03d78e74ae7f484GRADE VERY_LOW
psilocybin — cognition
direction BENEFIT · dose 0.17 mg/kg; 0.26 mg/kg; 1 mg/kg; 25 mg; 5 mg · duration UNSPECIFIED
Grade basis — weakest-link ceilings
MODERATEdesign
LOWdirectness
MODERATEextraction
LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
8bound studies
Bound studies (4 shown of 8)
STU-4450aac95872bf0aANIMAL · ANIMAL · 2023 · RoB INSUFFICIENT_INFORMATION
1 endpoints
STU-63999e78e4e7cd8dRCT · HUMAN · 2026 · RoB SOME_CONCERNS
2 endpoints
STU-8dbe8d4afd7b9945ANIMAL · ANIMAL · 2026 · RoB INSUFFICIENT_INFORMATION
1 endpoints
STU-91c8e6444a4cd826UNSPECIFIED · HUMAN · 2024 · RoB NOT_ASSESSABLE
2 endpoints
Quantitative observations
observation 1 mg/kg · validated
observation 105 · validated
observation 0.26 mg/kg · validated
Opposition screen
SCREEN · 17 candidates considered · 3 bound as opposing
SYNTHESIS SYN-e1bf461c6b157a — outcome QUALITATIVE_ONLY · BENEFIT ×8 · not_assessed_quantitatively · 8 members
PROVENANCE → epmc:37266686, epmc:PPR1303300, epmc:42754621 · PKG 90925e4e59c27627…
Bounded preview — representative records only. The full release ships 16 claims and 245 observations.