RECORD PREVIEW · FIELD RECORD ×2BOUNDED — REAL RELEASED DATA
CLAIM · CLM-6fb6ccc1ceb8a7aeGRADE VERY_LOW
milk thistle constituents — liver
direction BENEFIT · dose 100 mg/kg; 150 mg; 2 g; 200 mg/kg; 30 mg/kg; 4.0 g/kg; 560 mg; 600 mg/kg; 61.5 mg/kg; 70 mg · duration 12 week; 14 days; 21 days; 28 days; 3 weeks; 42 days; 5 days; 6 months; 70 days; 8 weeks
Grade basis — weakest-link ceilings
HIGHdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
28bound studies
Bound studies (4 shown of 28)
STU-0847c7ec1be99278ANIMAL · ANIMAL · 2023 · RoB INSUFFICIENT_INFORMATION
2 endpoints
STU-0c2df7fff7ce3251ANIMAL · ANIMAL · 2024 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-0c3c4e1033971a49IN_VITRO · IN_VITRO · 2020 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-1cd5975a7d6152bfANIMAL · ANIMAL · 2022 · RoB INSUFFICIENT_INFORMATION
3 endpoints
Quantitative observations
Opposition screen
SCREEN · 50 candidates considered · 0 bound as opposing
SYNTHESIS SYN-a53f5c48ad8a66 — outcome QUALITATIVE_ONLY · BENEFIT ×28 · not_assessed_quantitatively · 28 members
PROVENANCE → epmc:36851435, epmc:38396547, epmc:33327438 · PKG b9362057906a882c…
CLAIM · CLM-56ff670e5def2aa8GRADE VERY_LOW
milk thistle constituents — antioxidant
direction BENEFIT · dose 100 mg/kg; 200 mg/kg; 4.0 g/kg; 70 mg · duration 12 weeks; 28 days; 3 weeks; 4 weeks; 42 days; 6 months; 70 days
Grade basis — weakest-link ceilings
MODERATEdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
19bound studies
Bound studies (4 shown of 19)
STU-0847c7ec1be99278ANIMAL · ANIMAL · 2023 · RoB INSUFFICIENT_INFORMATION
2 endpoints
STU-0d188d7949455eb1RCT · HUMAN · 2026 · RoB SOME_CONCERNS
2 endpoints
STU-18b31562d9fb113eANIMAL · ANIMAL · 2024 · RoB INSUFFICIENT_INFORMATION
2 endpoints
STU-1cd5975a7d6152bfANIMAL · ANIMAL · 2022 · RoB INSUFFICIENT_INFORMATION
3 endpoints
Quantitative observations
p_value p < 0.001 · validated
n 60 · validated
dose 70 mg · validated
Opposition screen
SCREEN · 46 candidates considered · 0 bound as opposing
SYNTHESIS SYN-e1573622f86863 — outcome QUALITATIVE_ONLY · BENEFIT ×19 · not_assessed_quantitatively · 19 members
PROVENANCE → epmc:36851435, epmc:40762702, epmc:34599793 · PKG b9362057906a882c…
Bounded preview — representative records only. The full release ships 34 claims and 282 observations.