RECORD PREVIEW · FIELD RECORD ×2BOUNDED — REAL RELEASED DATA
CLAIM · CLM-b378cb19aa95fcdeGRADE VERY_LOW
coffee — weight
direction BENEFIT · dose 0.4 mg/kg; 400 mg/kg; 5 g; 592.0 g · duration 12 weeks; 4 weeks; 9 weeks
Grade basis — weakest-link ceilings
MODERATEdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
15bound studies
Bound studies (4 shown of 15)
STU-0f49702106f9819aRCT · HUMAN · 2024 · 12 weeks · RoB SOME_CONCERNS
2 endpoints
STU-3a074f54b3bae036IN_VITRO · IN_VITRO · 2020 · RoB INSUFFICIENT_INFORMATION
3 endpoints
STU-4ae02e0180f19a55UNSPECIFIED · HUMAN · 2025 · RoB NOT_ASSESSABLE
3 endpoints
STU-579621d2c9c7ce28CROSS_SECTIONAL · HUMAN · 2026 · RoB INSUFFICIENT_INFORMATION
2 endpoints
Quantitative observations
n 38 · validated
duration 12 weeks · failed extraction
p_value p < 0.001 · validated
Opposition screen
SCREEN · 43 candidates considered · 0 bound as opposing
SYNTHESIS SYN-dc4320d92d6995 — outcome QUALITATIVE_ONLY · BENEFIT ×15 · not_assessed_quantitatively · 15 members
PROVENANCE → epmc:39275165, epmc:40931582, epmc:41971704 · PKG cbb4d2e6e1ec5391…
CLAIM · CLM-1db7cf815992f79dGRADE VERY_LOW
coffee — cholesterol
direction BENEFIT · dose 200 mg/kg; 400 mg/kg; 5 g · duration 12 month; 4 weeks; 9 weeks
Grade basis — weakest-link ceilings
MODERATEdesign
LOWdirectness
LOWextraction
VERY_LOWconfidence
MODERATEmethodology
MODERATEconsistency
MODERATEnumeric
11bound studies
Bound studies (4 shown of 11)
STU-29cc231496ded869UNSPECIFIED · HUMAN · 2025 · RoB NOT_ASSESSABLE
3 endpoints
STU-34d2e76fc113af68RCT · HUMAN · 2024 · RoB SOME_CONCERNS
3 endpoints
STU-5822d9fdba520568RCT · HUMAN · 2025 · 12 month · RoB SOME_CONCERNS
3 endpoints
STU-85663ed6a8311451ANIMAL · ANIMAL · 2026 · 4 weeks · RoB SOME_CONCERNS
3 endpoints
Quantitative observations
n 40 · validated
duration 12 month · failed extraction
dose 400 mg/kg · validated
Opposition screen
SCREEN · 27 candidates considered · 0 bound as opposing
SYNTHESIS SYN-3bdad7379dd5f6 — outcome QUALITATIVE_ONLY · BENEFIT ×11 · not_assessed_quantitatively · 11 members
PROVENANCE → epmc:41531586, epmc:38571923, epmc:40868130 · PKG cbb4d2e6e1ec5391…
Bounded preview — representative records only. The full release ships 38 claims and 496 observations.