{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Turmeric",
 "slug": "turmeric",
 "dataset_id": "MFI-TURMER-20261008-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "489a602c5cf35b3f",
 "claims": [
  {
   "claim_id": "CLM-6a6b7e456bdbc1b7",
   "object": "turmeric constituents",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "META_ANALYSIS",
    "RCT",
    "SYSTEMATIC_REVIEW",
    "TRIAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "120 mg; 150 mg/kg; 1500 mg; 500 mg; 80 mg",
   "duration": "12 months; 14 day; 21 days; 3 months; 30 days; 42 days; 84 days; 90 days",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "LOW",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 39,
    "rob_worst_judgment": "HIGH_RISK"
   },
   "bound_studies": [
    {
     "study_id": "STU-038efdb3b38b48b3",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2018,
     "dose": null,
     "duration": "42 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": []
    },
    {
     "study_id": "STU-07933ddb977eea41",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": "30 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cognition": "BENEFIT",
      "immune": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40531286"
     ]
    },
    {
     "study_id": "STU-0efd886e36fc1a4d",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "gastrointestinal": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42589357"
     ]
    },
    {
     "study_id": "STU-1fcddeaa54b69e34",
     "design": "META_ANALYSIS",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cognition": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40918536"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-3571c6d0c1a7b1",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "42 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W2805485896"
    },
    {
     "observation_id": "QOB-5cb756e5eb946e",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.05 | p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W2805485896"
    },
    {
     "observation_id": "QOB-9b5232f9038ddb",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "30 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40531286"
    },
    {
     "observation_id": "QOB-ac9f2e8279d785",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.01",
     "original_representation": "p = 0.01",
     "original_unit": null,
     "normalized_value": 0.01,
     "normalized_unit": null,
     "endpoint": "mood",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40918536"
    },
    {
     "observation_id": "QOB-ff985423badb79",
     "observation_kind": "effect",
     "effect_measure": "standardized mean difference",
     "original_value": "-0.65",
     "original_representation": "smd: -0.65",
     "original_unit": null,
     "normalized_value": -0.65,
     "normalized_unit": null,
     "endpoint": "mood",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40918536"
    }
   ],
   "opposition": {
    "considered": 64,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-8fe783b60a2634",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 39
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-038efdb3b38b48b3",
     "STU-07933ddb977eea41",
     "STU-0efd886e36fc1a4d",
     "STU-1fcddeaa54b69e34",
     "STU-1ffec582fb26b1fb",
     "STU-2f036358697e1ecb",
     "STU-3b90e1e06798762d",
     "STU-3d509371b694d59e",
     "STU-43976f66244b14cd",
     "STU-4cf30c59823ac0c1",
     "STU-4d84dda85fa57c4f",
     "STU-5b88e7a802e6da9a",
     "STU-5d784c5234b0a199",
     "STU-6888506882c62a81",
     "STU-6b63969d49d2eb34",
     "STU-6c4d66f4788814c9",
     "STU-72af054213284bbc",
     "STU-7ba60f27dbb719ba",
     "STU-8b86cc5619b5a4d4",
     "STU-8c306468e60ac1be",
     "STU-973491029fdd6420",
     "STU-9b47b473bb606a94",
     "STU-9c2a0b1930d8f279",
     "STU-abd85906e1392a5f",
     "STU-b3a5a6ff97405796",
     "STU-b77a8f5646b464a8",
     "STU-bac14c567b016638",
     "STU-c070406ade3cec4c",
     "STU-cfaf73ee9398276f",
     "STU-d0f71c57323fb533",
     "STU-d52c44da028da2d2",
     "STU-d81e58b2f2cad1e4",
     "STU-d8f2f90aff37f29b",
     "STU-dd4cf4ea4afeb75e",
     "STU-ea7f31bb60062402",
     "STU-f242057b6ee97b15",
     "STU-f7cc6a9d1ab17fad",
     "STU-fa42e6dce27de0f1",
     "STU-fa5de2ff086242fb"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-25ebf712abe04ead",
   "object": "turmeric constituents",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "META_ANALYSIS",
    "RCT",
    "SYSTEMATIC_REVIEW",
    "TRIAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "1100 mg/kg; 150 mg/kg; 1500 mg; 30 mg/kg; 500 mg",
   "duration": "12 months; 16 week; 21 days; 30 days; 42 days; 84 days",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "LOW",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 26,
    "rob_worst_judgment": "HIGH_RISK"
   },
   "bound_studies": [
    {
     "study_id": "STU-038efdb3b38b48b3",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2018,
     "dose": null,
     "duration": "42 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": []
    },
    {
     "study_id": "STU-07933ddb977eea41",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": "30 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cognition": "BENEFIT",
      "immune": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40531286"
     ]
    },
    {
     "study_id": "STU-10cf46e5ea66b477",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": "16 week",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cardiovascular": "HARM",
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:40682175"
     ]
    },
    {
     "study_id": "STU-1115e8ae2bc719a4",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "skin": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42472502"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-3571c6d0c1a7b1",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "42 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W2805485896"
    },
    {
     "observation_id": "QOB-5cb756e5eb946e",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.05 | p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W2805485896"
    },
    {
     "observation_id": "QOB-9b5232f9038ddb",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "30 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40531286"
    },
    {
     "observation_id": "QOB-1b0ff1cdcb4d1a",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p = 0.787 | p = 0.576 | p = 0.405",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40682175"
    },
    {
     "observation_id": "QOB-2eda8a9793594b",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "16 week",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40682175"
    }
   ],
   "opposition": {
    "considered": 47,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-caa0dbc7043634",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 26
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-038efdb3b38b48b3",
     "STU-07933ddb977eea41",
     "STU-10cf46e5ea66b477",
     "STU-1115e8ae2bc719a4",
     "STU-1fcddeaa54b69e34",
     "STU-1ffec582fb26b1fb",
     "STU-4cf30c59823ac0c1",
     "STU-4d84dda85fa57c4f",
     "STU-593f08d1eee9c89a",
     "STU-5b88e7a802e6da9a",
     "STU-5d784c5234b0a199",
     "STU-6888506882c62a81",
     "STU-6c4d66f4788814c9",
     "STU-97ec11dcb13cbd4b",
     "STU-9b47b473bb606a94",
     "STU-abd85906e1392a5f",
     "STU-c070406ade3cec4c",
     "STU-c11de607314c90a6",
     "STU-d25471f8ee45b64e",
     "STU-d52c44da028da2d2",
     "STU-d9cfcde8942845c0",
     "STU-e06b0e9a71dd40c8",
     "STU-e2e066d40496154a",
     "STU-e78058ad731dcdee",
     "STU-ea7f31bb60062402",
     "STU-fa42e6dce27de0f1"
    ],
    "observations_pooled": 0
   }
  }
 ]
}