{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Stinging Nettle",
 "slug": "stinging-nettle",
 "dataset_id": "MFI-STNETT-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "fc5f5ef3ba474877",
 "claims": [
  {
   "claim_id": "CLM-206c8dbc558357a6",
   "object": "stinging nettle constituents",
   "outcome": "immune",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 3,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 3,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-4448558b1c02ebff",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2016,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:IND605265206"
     ]
    },
    {
     "study_id": "STU-4b30f2e4777e5769",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2013,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:23092723"
     ]
    },
    {
     "study_id": "STU-93ba114a34111c11",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2017,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:28544187"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-cf11cc83f5a8c8",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p<0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:IND605265206"
    },
    {
     "observation_id": "QOB-dfd63948ed3260",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 10,
     "original_representation": "10",
     "original_unit": null,
     "normalized_value": 10.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:IND605265206"
    },
    {
     "observation_id": "QOB-f3fb91537c8500",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.01",
     "original_representation": "p<0.01",
     "original_unit": null,
     "normalized_value": 0.01,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:IND605265206"
    }
   ],
   "opposition": {
    "considered": 5,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-696dcea5826b5e",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 3
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-4448558b1c02ebff",
     "STU-4b30f2e4777e5769",
     "STU-93ba114a34111c11"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-03e20ba4271dd0d1",
   "object": "stinging nettle constituents",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "IN_VITRO",
    "UNSPECIFIED"
   ],
   "models": [
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 2,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 0,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-4b30f2e4777e5769",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2013,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:23092723"
     ]
    },
    {
     "study_id": "STU-93ba114a34111c11",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2017,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:28544187"
     ]
    }
   ],
   "quantitative_observations": [],
   "opposition": {
    "considered": 4,
    "bound": 2
   },
   "synthesis": {
    "synthesis_id": "SYN-d7c0d9adb07a02",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 2
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-4b30f2e4777e5769",
     "STU-93ba114a34111c11"
    ],
    "observations_pooled": 0
   }
  }
 ]
}