{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Saffron",
 "slug": "saffron",
 "dataset_id": "MFI-SAFFRO-20261013-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "d3d54fd1fa19a95b",
 "claims": [
  {
   "claim_id": "CLM-eb3452c6cba2f813",
   "object": "saffron",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "META_ANALYSIS",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "100 mg; 200 mg; 30 mg; 400 mg",
   "duration": "12 weeks; 14 weeks; 21 days; 60 days; 7 days; 8 weeks",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 18,
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-1f6a5e8535c7d1f2",
     "design": "META_ANALYSIS",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:39657222"
     ]
    },
    {
     "study_id": "STU-2ebec11c4432b9df",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2023,
     "dose": null,
     "duration": "12 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "inflammation": "BENEFIT",
      "mood": "BENEFIT",
      "mortality": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:37801956"
     ]
    },
    {
     "study_id": "STU-39075b3335e4243a",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": "12 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cognition": "BENEFIT",
      "exercise": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:41439298"
     ]
    },
    {
     "study_id": "STU-576a88f5cfe48628",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": null,
     "duration": "14 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41674224"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-44a4007de392f8",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": ".15",
     "original_representation": "p = .15",
     "original_unit": null,
     "normalized_value": 0.15,
     "normalized_unit": null,
     "endpoint": "inflammation",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39657222"
    },
    {
     "observation_id": "QOB-ff6c5c3f475185",
     "observation_kind": "effect",
     "effect_measure": "standardized mean difference",
     "original_value": "-0.38",
     "original_representation": "smd: -0.38",
     "original_unit": null,
     "normalized_value": -0.38,
     "normalized_unit": null,
     "endpoint": "inflammation",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39657222"
    },
    {
     "observation_id": "QOB-062c014764f107",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.05 | p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:37801956"
    },
    {
     "observation_id": "QOB-d0fff654c17474",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:37801956"
    },
    {
     "observation_id": "QOB-44e17c10ca657a",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 92,
     "original_representation": "92",
     "original_unit": null,
     "normalized_value": 92.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:41439298"
    },
    {
     "observation_id": "QOB-7075a3b17499b6",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41439298"
    }
   ],
   "opposition": {
    "considered": 45,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-39c2b4f6d7f59f",
    "synthesis_outcome": "PARTIAL_SYNTHESIS",
    "direction_tally": {
     "BENEFIT": 18
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-1f6a5e8535c7d1f2",
     "STU-2ebec11c4432b9df",
     "STU-39075b3335e4243a",
     "STU-576a88f5cfe48628",
     "STU-5f5c90ddcc391579",
     "STU-707beff13d8901ff",
     "STU-70b4075e92fa9921",
     "STU-7aa56a704d8db1d5",
     "STU-7ac7f36e508de9a3",
     "STU-81fa55780f57c913",
     "STU-96dcd0f041eea1a9",
     "STU-b310572b697c9df9",
     "STU-b3b2361cd53e3bd5",
     "STU-be681a5a1715877d",
     "STU-cc463a66a01baee9",
     "STU-ccc822655a7a6d1c",
     "STU-dab855d7b7b25861",
     "STU-e27dfd28fa175583"
    ],
    "observations_pooled": 2
   }
  },
  {
   "claim_id": "CLM-3882fad77e747e4b",
   "object": "saffron",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "META_ANALYSIS",
    "RCT",
    "SYSTEMATIC_REVIEW",
    "TRIAL"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "100 mg; 15 mg; 20 mg",
   "duration": "12 months; 12 weeks; 14 weeks; 21 days; 35 days; 7 days",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "LOW",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 14,
    "rob_worst_judgment": "HIGH_RISK"
   },
   "bound_studies": [
    {
     "study_id": "STU-01811c120a686465",
     "design": "META_ANALYSIS",
     "model": "HUMAN",
     "publication_year": 2023,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:36817799"
     ]
    },
    {
     "study_id": "STU-1f6a5e8535c7d1f2",
     "design": "META_ANALYSIS",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:39657222"
     ]
    },
    {
     "study_id": "STU-39075b3335e4243a",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": "12 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cognition": "BENEFIT",
      "exercise": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:41439298"
     ]
    },
    {
     "study_id": "STU-576a88f5cfe48628",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": null,
     "duration": "14 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41674224"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-70782e08b29c74",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "smd: -0.322 | smd: -0.654 | smd: 0.302 | smd: 0.447",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:36817799"
    },
    {
     "observation_id": "QOB-e09203e02083d0",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 466,
     "original_representation": "466",
     "original_unit": null,
     "normalized_value": 466.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:36817799"
    },
    {
     "observation_id": "QOB-44a4007de392f8",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": ".15",
     "original_representation": "p = .15",
     "original_unit": null,
     "normalized_value": 0.15,
     "normalized_unit": null,
     "endpoint": "inflammation",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39657222"
    },
    {
     "observation_id": "QOB-ff6c5c3f475185",
     "observation_kind": "effect",
     "effect_measure": "standardized mean difference",
     "original_value": "-0.38",
     "original_representation": "smd: -0.38",
     "original_unit": null,
     "normalized_value": -0.38,
     "normalized_unit": null,
     "endpoint": "inflammation",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39657222"
    },
    {
     "observation_id": "QOB-44e17c10ca657a",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 92,
     "original_representation": "92",
     "original_unit": null,
     "normalized_value": 92.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:41439298"
    },
    {
     "observation_id": "QOB-7075a3b17499b6",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41439298"
    }
   ],
   "opposition": {
    "considered": 38,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-4dc4815c702ef6",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 14
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-01811c120a686465",
     "STU-1f6a5e8535c7d1f2",
     "STU-39075b3335e4243a",
     "STU-576a88f5cfe48628",
     "STU-61a4d325187733b1",
     "STU-6a87e45360aa5664",
     "STU-70b4075e92fa9921",
     "STU-81fa55780f57c913",
     "STU-9203bafcf926aa01",
     "STU-aa7250784bb8fae4",
     "STU-b310572b697c9df9",
     "STU-b3b2361cd53e3bd5",
     "STU-ccc822655a7a6d1c",
     "STU-d90e68fc7b6f6d39"
    ],
    "observations_pooled": 0
   }
  }
 ]
}