{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Rhodiola",
 "slug": "rhodiola",
 "dataset_id": "MFI-RHODIO-20261019-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "8dd069b2d2d7b28f",
 "claims": [
  {
   "claim_id": "CLM-0417fa37cb86613f",
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   "outcome": "antioxidant",
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   "grade": "VERY_LOW",
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    "ANIMAL",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "IN_VITRO"
   ],
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   "duration": "14 days; 45 days; 8 week",
   "grade_basis": {
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    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 6,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
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     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "inflammation": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
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    },
    {
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "UNCERTAIN",
      "cholesterol": "UNCERTAIN",
      "exercise": "UNCERTAIN",
      "glucose": "UNCERTAIN",
      "inflammation": "UNCERTAIN",
      "liver": "UNCERTAIN",
      "sleep": "UNCERTAIN"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:39203919"
     ]
    },
    {
     "study_id": "STU-af294ba597eaba33",
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     "model": "ANIMAL",
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     "dose": null,
     "duration": "14 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "HARM",
      "cancer": "HARM",
      "inflammation": "HARM"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
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     ]
    },
    {
     "study_id": "STU-b64bf872d2e2801f",
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     "model": "ANIMAL",
     "publication_year": 2022,
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     "duration": "8 week",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "UNCERTAIN",
      "cardiovascular": "HARM",
      "exercise": "BENEFIT",
      "glucose": "UNCERTAIN",
      "mood": "UNCERTAIN"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:36434120"
     ]
    }
   ],
   "quantitative_observations": [
    {
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     "observation_kind": "dose",
     "effect_measure": "dose",
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     "original_representation": "130 mg/kg",
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     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
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    },
    {
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     "original_unit": "mg/kg",
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     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:39203919"
    },
    {
     "observation_id": "QOB-63832e2fa19357",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.01 | p < 0.01",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:39192656"
    },
    {
     "observation_id": "QOB-7a137d3e5a729a",
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     "effect_measure": "duration",
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     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:35432571"
    },
    {
     "observation_id": "QOB-8f3ee23913ede7",
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     "effect_measure": "duration",
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     "original_unit": null,
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     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41695889"
    }
   ],
   "opposition": {
    "considered": 8,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-5945bc16941ae1",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 1,
     "HARM": 1,
     "UNCERTAIN": 3
    },
    "directional_disagreement": true,
    "heterogeneity": "directional_disagreement",
    "study_members": [
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     "STU-5dc7691f70d9a470",
     "STU-af294ba597eaba33",
     "STU-b64bf872d2e2801f",
     "STU-cef3460485e0bc72"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-a9fc7570e04cfe3a",
   "object": "rhodiola",
   "outcome": "mood",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "130 mg/kg; 154 mg; 400 mg",
   "duration": "12 weeks; 45 days; 6 weeks",
   "grade_basis": {
    "bound_studies": 5,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 8,
    "rob_cap": "LOW",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-1001a4547cc8eafd",
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     "model": "ANIMAL",
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     "duration": "45 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "inflammation": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:41695889"
     ]
    },
    {
     "study_id": "STU-87bc3850f22214df",
     "design": "RCT",
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     "publication_year": 2018,
     "dose": "154 mg",
     "duration": "6 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:30034237"
     ]
    },
    {
     "study_id": "STU-97a884b94a1383d0",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2017,
     "dose": "400 mg",
     "duration": "12 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "HIGH_RISK",
     "provenance_refs": [
      "epmc:28367055"
     ]
    },
    {
     "study_id": "STU-9c2a05db9e083495",
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     "model": "ANIMAL",
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "exercise": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40172490"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-05e4ca581772a2",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 41,
     "original_representation": "41",
     "original_unit": null,
     "normalized_value": 41.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
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    },
    {
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     "original_representation": "130 mg/kg",
     "original_unit": "mg/kg",
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     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
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    },
    {
     "observation_id": "QOB-604a2cc9265fb6",
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     "original_unit": null,
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     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
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    },
    {
     "observation_id": "QOB-873f382b5e46c6",
     "observation_kind": "dose",
     "effect_measure": "dose",
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     "original_representation": "400 mg",
     "original_unit": "mg",
     "normalized_value": 400.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
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    },
    {
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   ],
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   },
   "synthesis": {
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    },
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    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
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     "STU-fbbf3aba1f8618c8"
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    "observations_pooled": 0
   }
  }
 ]
}