{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Psilocybe",
 "slug": "psilocybe",
 "dataset_id": "MFI-PSILOC-20261029-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "90925e4e59c27627",
 "claims": [
  {
   "claim_id": "CLM-1dc1efb1d5118072",
   "object": "psilocybin",
   "outcome": "mood",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "META_ANALYSIS",
    "RCT",
    "SYSTEMATIC_REVIEW",
    "TRIAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "0.17 mg/kg; 0.32 mg/kg; 0.88 mg/kg; 25 mg; 30 mg; 4.4 mg/kg; 5 mg",
   "duration": "16 weeks; 21 days",
   "grade_basis": {
    "bound_studies": 23,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 29,
    "rob_cap": "LOW",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-144b3da5e1cfc5ad",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2023,
     "dose": "0.88 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "inflammation": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:36985596"
     ]
    },
    {
     "study_id": "STU-196a555812675bd5",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:39973494"
     ]
    },
    {
     "study_id": "STU-1f1562a5755657be",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": "25 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT",
      "mortality": "UNCERTAIN"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:40858059"
     ]
    },
    {
     "study_id": "STU-3e0f40cb1ac7527c",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:PPR1304856"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-11c65fa1b6acee",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.001",
     "original_representation": "p < 0.001",
     "original_unit": null,
     "normalized_value": 0.001,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:36513161"
    },
    {
     "observation_id": "QOB-1a07001f5d4b3d",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "16 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.1503/jpn.120128"
    },
    {
     "observation_id": "QOB-1e93236043b718",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 5,
     "original_representation": "5",
     "original_unit": null,
     "normalized_value": 5.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:42567236"
    },
    {
     "observation_id": "QOB-263b87bcfd314e",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": ".02",
     "original_representation": "p = .02",
     "original_unit": null,
     "normalized_value": 0.02,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40858059"
    },
    {
     "observation_id": "QOB-399af1da293361",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "0.17",
     "original_representation": "0.17 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 0.17,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:PPR1296547"
    }
   ],
   "opposition": {
    "considered": 45,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-f961a7650498fe",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 23
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-144b3da5e1cfc5ad",
     "STU-196a555812675bd5",
     "STU-1f1562a5755657be",
     "STU-3e0f40cb1ac7527c",
     "STU-3f7d67c9ca82a41d",
     "STU-4dc2060484b9c532",
     "STU-5c2c62f1e0d695dc",
     "STU-63999e78e4e7cd8d",
     "STU-642d067a43f74144",
     "STU-646a29a8495fa5fa",
     "STU-84a6c05e7c8b8cd3",
     "STU-8d0a8eed99a97399",
     "STU-8f3c1a29a816d0d7",
     "STU-91c8e6444a4cd826",
     "STU-9908ced77f68e6df",
     "STU-ac79bf1844343b1c",
     "STU-b3c7adf9d1458c7a",
     "STU-c1d15567f88a4473",
     "STU-dc0387fd660a7125",
     "STU-e58acd96304be876",
     "STU-f192c3dc7a586e37",
     "STU-f5a275680eb8fe67",
     "STU-fe6ee91c738e21fe"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-a03d78e74ae7f484",
   "object": "psilocybin",
   "outcome": "cognition",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "COHORT",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "0.17 mg/kg; 0.26 mg/kg; 1 mg/kg; 25 mg; 5 mg",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 8,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 10,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-4450aac95872bf0a",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2023,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cognition": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:37266686"
     ]
    },
    {
     "study_id": "STU-63999e78e4e7cd8d",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": "5 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cognition": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:PPR1303300"
     ]
    },
    {
     "study_id": "STU-8dbe8d4afd7b9945",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": "1 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cognition": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42754621"
     ]
    },
    {
     "study_id": "STU-91c8e6444a4cd826",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": "25 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cognition": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:39266503"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-60e1e80671412c",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "1",
     "original_representation": "1 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 1.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:41193674"
    },
    {
     "observation_id": "QOB-6b87cdcadb6b1d",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 105,
     "original_representation": "105",
     "original_unit": null,
     "normalized_value": 105.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:42559191"
    },
    {
     "observation_id": "QOB-846ded3ad32c6a",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "0.26",
     "original_representation": "0.26 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 0.26,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:35743788"
    },
    {
     "observation_id": "QOB-9fcdfbfc86d8ae",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "5",
     "original_representation": "5 mg",
     "original_unit": "mg",
     "normalized_value": 5.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:PPR1303300"
    },
    {
     "observation_id": "QOB-af1e6cbe891e06",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "25",
     "original_representation": "25 mg",
     "original_unit": "mg",
     "normalized_value": 25.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:39266503"
    }
   ],
   "opposition": {
    "considered": 17,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-e1bf461c6b157a",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 8
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-4450aac95872bf0a",
     "STU-63999e78e4e7cd8d",
     "STU-8dbe8d4afd7b9945",
     "STU-91c8e6444a4cd826",
     "STU-b3c7adf9d1458c7a",
     "STU-c0b49f4480badd8e",
     "STU-e1a978ed873935fb",
     "STU-f51ed7d9d2a60d06"
    ],
    "observations_pooled": 0
   }
  }
 ]
}