{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Poria",
 "slug": "poria",
 "dataset_id": "MFI-PORIA-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "e8b64678e52e85fc",
 "claims": [
  {
   "claim_id": "CLM-b053c93cd3427c5c",
   "object": "poria",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
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    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 2,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-7fe689418082ff40",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "inflammation": "BENEFIT",
      "kidney": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40864644"
     ]
    },
    {
     "study_id": "STU-b6030107ace88cde",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "inflammation": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:39106701"
     ]
    },
    {
     "study_id": "STU-e3bc6cc3d5c1774f",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2023,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:37168053"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-22a12e186ce00b",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p < 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39106701"
    },
    {
     "observation_id": "QOB-9f4f2310be78e8",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:39106701"
    }
   ],
   "opposition": {
    "considered": 9,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-99bc48c3f97237",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 3
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-7fe689418082ff40",
     "STU-b6030107ace88cde",
     "STU-e3bc6cc3d5c1774f"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-6b236ebf62808ad3",
   "object": "poria constituents",
   "outcome": "cancer",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "21 days",
   "grade_basis": {
    "bound_studies": 2,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 1,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-3121d3d7f87c0e95",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2023,
     "dose": null,
     "duration": "21 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "inflammation": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:37240380"
     ]
    },
    {
     "study_id": "STU-3746f3a60e1feaea",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:PPR1158054"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-2d8941b4ba3bda",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "21 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:37240380"
    }
   ],
   "opposition": {
    "considered": 3,
    "bound": 1
   },
   "synthesis": {
    "synthesis_id": "SYN-9b3c4fd4ba74c0",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 2
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-3121d3d7f87c0e95",
     "STU-3746f3a60e1feaea"
    ],
    "observations_pooled": 0
   }
  }
 ]
}