{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Phellinus Linteus",
 "slug": "phellinus-linteus",
 "dataset_id": "MFI-PHELLI-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "6111408b7f0f8478",
 "claims": [
  {
   "claim_id": "CLM-7e9ad759eb4533d2",
   "object": "phellinus linteus constituents",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "dose": "100 mg/kg; 200 mg/kg",
   "duration": "4 weeks",
   "grade_basis": {
    "bound_studies": 8,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 5,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-1c63eb3c630f23d1",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2012,
     "dose": "200 mg/kg",
     "duration": "4 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:23075396"
     ]
    },
    {
     "study_id": "STU-3a8b10d601eee983",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2014,
     "dose": "100 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "glucose": "BENEFIT",
      "immune": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:24761950"
     ]
    },
    {
     "study_id": "STU-49e0d16167382bdc",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2007,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "antioxidant": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.1002/ptr.2182"
     ]
    },
    {
     "study_id": "STU-9a4f17263952675f",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:33542742"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-621f32dfef94bd",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "100",
     "original_representation": "100 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 100.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:24761950"
    },
    {
     "observation_id": "QOB-7c9ec9c9361925",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "200",
     "original_representation": "200 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 200.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:40497052"
    },
    {
     "observation_id": "QOB-960cdaf2aa1361",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "200",
     "original_representation": "200 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 200.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:23075396"
    },
    {
     "observation_id": "QOB-dacf1673eb603f",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "decreased, sod activity reduced by 45% | increased by 66% | p < 0.05 | p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40598329"
    },
    {
     "observation_id": "QOB-f20e538a212b0b",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "4 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:23075396"
    }
   ],
   "opposition": {
    "considered": 11,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-902f1d330f2a7c",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 8
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-1c63eb3c630f23d1",
     "STU-3a8b10d601eee983",
     "STU-49e0d16167382bdc",
     "STU-9a4f17263952675f",
     "STU-9aa37cfb013b2819",
     "STU-b14668042c7670cd",
     "STU-b91ea954be40b651",
     "STU-f766ec313158513c"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-2fdba8ea8c207fbc",
   "object": "phellinus linteus constituents",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "7 days; 8 weeks",
   "grade_basis": {
    "bound_studies": 6,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 6,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-3f76d05a45037cb6",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2022,
     "dose": null,
     "duration": "8 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:36221338"
     ]
    },
    {
     "study_id": "STU-51641eb14789a991",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": null,
     "duration": "7 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "inflammation": "BENEFIT",
      "microbiome": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:PPR1188680"
     ]
    },
    {
     "study_id": "STU-5f6825c096d4b630",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2017,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "gastrointestinal": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:29085494"
     ]
    },
    {
     "study_id": "STU-7a1fd8ceda83c911",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2020,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "glucose": "BENEFIT",
      "inflammation": "BENEFIT",
      "microbiome": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:31914668"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-068271254f567f",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "7 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:PPR1188680"
    },
    {
     "observation_id": "QOB-4ecd06f0d1fb44",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "8 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:36221338"
    },
    {
     "observation_id": "QOB-79255c5497d174",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < .05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:36042633"
    },
    {
     "observation_id": "QOB-7acbd91320b26b",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "8 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:36042633"
    },
    {
     "observation_id": "QOB-7de2ccc2650f24",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 10,
     "original_representation": "10",
     "original_unit": null,
     "normalized_value": 10.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:36221338"
    }
   ],
   "opposition": {
    "considered": 13,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-964503bcf1d20e",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 6
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-3f76d05a45037cb6",
     "STU-51641eb14789a991",
     "STU-5f6825c096d4b630",
     "STU-7a1fd8ceda83c911",
     "STU-80ec610f7c492b0d",
     "STU-f766ec313158513c"
    ],
    "observations_pooled": 0
   }
  }
 ]
}