{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Oyster Mushroom",
 "slug": "oyster-mushroom",
 "dataset_id": "MFI-OYSTER-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "3473bc08fcf962aa",
 "claims": [
  {
   "claim_id": "CLM-035fd13ea4d8d36a",
   "object": "oyster mushroom",
   "outcome": "weight",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "12 weeks",
   "grade_basis": {
    "bound_studies": 6,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 5,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-6d038ee9e73ab730",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2023,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "BENEFIT",
      "mortality": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:PPR653832"
     ]
    },
    {
     "study_id": "STU-997fd055037d2527",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "liver": "BENEFIT",
      "microbiome": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:38609215"
     ]
    },
    {
     "study_id": "STU-a1137423feece2fe",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:38194011"
     ]
    },
    {
     "study_id": "STU-a6295237e4908d74",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2011,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:22783072"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-36f145b51ad881",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p< 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:PPR653832"
    },
    {
     "observation_id": "QOB-386135e204938d",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:39472483"
    },
    {
     "observation_id": "QOB-64e7da03338b11",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.001 | p < 0.001",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:38194011"
    },
    {
     "observation_id": "QOB-6d3594923775a6",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p < 0.05 | p < 0.05 | p < 0.01 | p < 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:39472483"
    },
    {
     "observation_id": "QOB-800a772d55981d",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p < 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:38194011"
    }
   ],
   "opposition": {
    "considered": 14,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-6081ff47fc7148",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 6
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-6d038ee9e73ab730",
     "STU-997fd055037d2527",
     "STU-a1137423feece2fe",
     "STU-a6295237e4908d74",
     "STU-acdf8e69e8581151",
     "STU-dc7360f2cc51f699"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-5949aa16ceaca8a8",
   "object": "oyster mushroom constituents",
   "outcome": "liver",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL"
   ],
   "models": [
    "ANIMAL"
   ],
   "dose": "200 mg/kg",
   "duration": "28 days; 7 days; 8 weeks",
   "grade_basis": {
    "bound_studies": 6,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 6,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-12c95497e111af77",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2017,
     "dose": null,
     "duration": "8 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "glucose": "BENEFIT",
      "kidney": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:29345562"
     ]
    },
    {
     "study_id": "STU-317453d2535519d2",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2007,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:17126515"
     ]
    },
    {
     "study_id": "STU-339240b7a9822ee9",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2010,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "glucose": "BENEFIT",
      "kidney": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:20673055"
     ]
    },
    {
     "study_id": "STU-5388ecb2397ca216",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2013,
     "dose": null,
     "duration": "7 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:23104078"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-0307930eea3b88",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "8 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:29345562"
    },
    {
     "observation_id": "QOB-05750761344d3d",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": ".05",
     "original_representation": "p < .05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:20673055"
    },
    {
     "observation_id": "QOB-acbbe1edab1864",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "28 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:38472823"
    },
    {
     "observation_id": "QOB-e2c5e5d78b88df",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "7 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:23104078"
    },
    {
     "observation_id": "QOB-f18c49a4c2c736",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "200",
     "original_representation": "200 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 200.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:38472823"
    }
   ],
   "opposition": {
    "considered": 13,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-f9431439fd8f5b",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 6
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-12c95497e111af77",
     "STU-317453d2535519d2",
     "STU-339240b7a9822ee9",
     "STU-5388ecb2397ca216",
     "STU-6a374977e2596139",
     "STU-dccb5c0f1603d02b"
    ],
    "observations_pooled": 0
   }
  }
 ]
}