{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Milk Thistle",
 "slug": "milk-thistle",
 "dataset_id": "MFI-MILKTH-20261014-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "b9362057906a882c",
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    "IN_VITRO",
    "META_ANALYSIS",
    "RCT",
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    "HUMAN",
    "IN_VITRO"
   ],
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   "duration": "12 week; 14 days; 21 days; 28 days; 3 weeks; 42 days; 5 days; 6 months; 70 days; 8 weeks",
   "grade_basis": {
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    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
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    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
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    },
    {
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "glucose": "BENEFIT",
      "inflammation": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
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    },
    {
     "study_id": "STU-0c3c4e1033971a49",
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
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    {
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     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
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      "cholesterol": "BENEFIT",
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     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34599793"
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   ],
   "quantitative_observations": [],
   "opposition": {
    "considered": 50,
    "bound": 0
   },
   "synthesis": {
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    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
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    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
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  {
   "claim_id": "CLM-56ff670e5def2aa8",
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   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
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    "IN_VITRO",
    "RCT",
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   ],
   "models": [
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    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "100 mg/kg; 200 mg/kg; 4.0 g/kg; 70 mg",
   "duration": "12 weeks; 28 days; 3 weeks; 4 weeks; 42 days; 6 months; 70 days",
   "grade_basis": {
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 19,
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
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     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
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    },
    {
     "study_id": "STU-0d188d7949455eb1",
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     "publication_year": 2026,
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "kidney": "NO_EFFECT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
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    },
    {
     "study_id": "STU-18b31562d9fb113e",
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     "publication_year": 2024,
     "dose": "100 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": []
    },
    {
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     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
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     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
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   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-2f045deca59adb",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.001",
     "original_representation": "p < 0.001",
     "original_unit": null,
     "normalized_value": 0.001,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
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    {
     "observation_id": "QOB-89993732679b67",
     "observation_kind": "n",
     "effect_measure": "sample size",
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     "original_representation": "60",
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     "normalized_unit": "mg",
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     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
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    {
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     "original_representation": "100 mg/kg",
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     "normalized_value": 100.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
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     "original_representation": "p<0.001 | p<0.001",
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     "extraction_state": "FAILED_EXTRACTION",
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     "transformation": "NONE",
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   "opposition": {
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  }
 ]
}