{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Maitake",
 "slug": "maitake",
 "dataset_id": "MFI-MAITAK-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "0bfa123f709c5040",
 "claims": [
  {
   "claim_id": "CLM-ffeb189c35a7d33e",
   "object": "maitake",
   "outcome": "immune",
   "direction": "UNCERTAIN",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "5 mg/kg",
   "duration": "12 week; 14 days; 15 days",
   "grade_basis": {
    "bound_studies": 6,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "VERY_LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 6,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-2b6fe2624fd159e4",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2016,
     "dose": "5 mg/kg",
     "duration": "15 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "immune": "UNCERTAIN",
      "mortality": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.1002/cam4.744"
     ]
    },
    {
     "study_id": "STU-31ef93a2178e99cc",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2014,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "immune": "UNCERTAIN",
      "inflammation": "UNCERTAIN"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:25332990"
     ]
    },
    {
     "study_id": "STU-5f4fd0eb56781e9a",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2022,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cancer": "HARM",
      "immune": "HARM"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "crf:10.18388/abp.2020_5996"
     ]
    },
    {
     "study_id": "STU-6b37548b151295f9",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2017,
     "dose": null,
     "duration": "12 week",
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "immune": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.31989/ffhd.v7i7.363"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-0043f85e172f93",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 50,
     "original_representation": "50",
     "original_unit": null,
     "normalized_value": 50.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.31989/ffhd.v7i7.363"
    },
    {
     "observation_id": "QOB-1f34ff1f11197d",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "5",
     "original_representation": "5 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 5.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "crf:10.1002/cam4.744"
    },
    {
     "observation_id": "QOB-5e4051db9f6405",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 141,
     "original_representation": "141",
     "original_unit": null,
     "normalized_value": 141.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.18388/abp.2020_5996"
    },
    {
     "observation_id": "QOB-6af3f6ce50a96d",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "14 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.1158/1940-6215.prev-13-b22"
    },
    {
     "observation_id": "QOB-b0055b607886f7",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 week",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.31989/ffhd.v7i7.363"
    }
   ],
   "opposition": {
    "considered": 9,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-91b5f4a45dbccf",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 1,
     "HARM": 1,
     "UNCERTAIN": 4
    },
    "directional_disagreement": true,
    "heterogeneity": "directional_disagreement",
    "study_members": [
     "STU-2b6fe2624fd159e4",
     "STU-31ef93a2178e99cc",
     "STU-5f4fd0eb56781e9a",
     "STU-6b37548b151295f9",
     "STU-da77e29db18275d5",
     "STU-dc31561355be5779"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-154110f14e39e4a4",
   "object": "maitake constituents",
   "outcome": "glucose",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL"
   ],
   "models": [
    "ANIMAL"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 4,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 2,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-291cf316fbbab5b7",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2018,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.1080/09168451.2018.1480348"
     ]
    },
    {
     "study_id": "STU-4404389ccb6cca9e",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2009,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.3181/0807-rm-226"
     ]
    },
    {
     "study_id": "STU-9403606790f7010d",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2008,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "oax:https://openalex.org/W2388625686"
     ]
    },
    {
     "study_id": "STU-9dda7d110815f385",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2015,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "crf:10.1039/c5fo00497g"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-2ad7cd34c6c9be",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.0005",
     "original_representation": "p = 0.0005",
     "original_unit": null,
     "normalized_value": 0.0005,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.3181/0807-rm-226"
    },
    {
     "observation_id": "QOB-38295e819a57ae",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p = 0.002 | p = 0.002",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.3181/0807-rm-226"
    }
   ],
   "opposition": {
    "considered": 6,
    "bound": 1
   },
   "synthesis": {
    "synthesis_id": "SYN-3ef062b0f11f0c",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 4
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-291cf316fbbab5b7",
     "STU-4404389ccb6cca9e",
     "STU-9403606790f7010d",
     "STU-9dda7d110815f385"
    ],
    "observations_pooled": 0
   }
  }
 ]
}