{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Maca",
 "slug": "maca",
 "dataset_id": "MFI-MACA-20261019-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "e4b9c334b6f31a03",
 "claims": [
  {
   "claim_id": "CLM-6d52c7ca4805849a",
   "object": "maca constituents",
   "outcome": "cholesterol",
   "direction": "BENEFIT",
   "grade": "LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "TRIAL"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "0.5625 mg/kg; 0.75 g/kg; 1.0 g/kg",
   "duration": "42 day",
   "grade_basis": {
    "bound_studies": 5,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 5,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-1de04deb0f425e37",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "UNCERTAIN",
      "cholesterol": "BENEFIT",
      "mortality": "UNCERTAIN",
      "skin": "UNCERTAIN"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42346117"
     ]
    },
    {
     "study_id": "STU-4c40d179e4a276ea",
     "design": "TRIAL",
     "model": "HUMAN",
     "publication_year": 2006,
     "dose": "0.75 g/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "mood": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:23674962"
     ]
    },
    {
     "study_id": "STU-c5139385dc3e60ed",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2020,
     "dose": "0.5625 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:32954883"
     ]
    },
    {
     "study_id": "STU-da235505c356ad5e",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34136157"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-24a9f56b023ecc",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "0.75",
     "original_representation": "0.75 g/kg",
     "original_unit": "g/kg",
     "normalized_value": 0.75,
     "normalized_unit": "g/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:23674962"
    },
    {
     "observation_id": "QOB-4054d9d6933ab5",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "1.0",
     "original_representation": "1.0 g/kg",
     "original_unit": "g/kg",
     "normalized_value": 1.0,
     "normalized_unit": "g/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:35867215"
    },
    {
     "observation_id": "QOB-4160b454e7e469",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "42 day",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:35867215"
    },
    {
     "observation_id": "QOB-6de35b4210a08b",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "0.5625",
     "original_representation": "0.5625 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 0.5625,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:32954883"
    },
    {
     "observation_id": "QOB-95df450d69ae1d",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p < 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:35867215"
    }
   ],
   "opposition": {
    "considered": 5,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-fd03b176301adb",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 5
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-1de04deb0f425e37",
     "STU-4c40d179e4a276ea",
     "STU-c5139385dc3e60ed",
     "STU-da235505c356ad5e",
     "STU-f1116cf798cf59ab"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-1f4dfc79d3952f2d",
   "object": "maca constituents",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "28 days",
   "grade_basis": {
    "bound_studies": 5,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 1,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-0779b638b589f32d",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "mood": "BENEFIT",
      "skin": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42196450"
     ]
    },
    {
     "study_id": "STU-429a5c33d895f2f4",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2022,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "liver": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:36296947"
     ]
    },
    {
     "study_id": "STU-882395279313a289",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2017,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT",
      "skin": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:28846044"
     ]
    },
    {
     "study_id": "STU-8deeab0454ff6dc8",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2022,
     "dose": null,
     "duration": "28 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "mortality": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:IND607501694"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-d1410e1e48c719",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "28 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:IND607501694"
    }
   ],
   "opposition": {
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    "bound": 3
   },
   "synthesis": {
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    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
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    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
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     "STU-429a5c33d895f2f4",
     "STU-882395279313a289",
     "STU-8deeab0454ff6dc8",
     "STU-da235505c356ad5e"
    ],
    "observations_pooled": 0
   }
  }
 ]
}