{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Krill Oil",
 "slug": "krill-oil",
 "dataset_id": "MFI-KRILLO-20261014-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "acd7a15d0e452848",
 "claims": [
  {
   "claim_id": "CLM-347049ae357f653a",
   "object": "krill oil constituents",
   "outcome": "cholesterol",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "META_ANALYSIS",
    "RCT",
    "TRIAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "100 mg/kg; 2 g; 4 g",
   "duration": "10 weeks; 28 day; 28 days; 6 weeks; 8 weeks",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 18,
    "rob_worst_judgment": "SOME_CONCERNS"
   },
   "bound_studies": [
    {
     "study_id": "STU-05d71ddf0224651f",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2013,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "cognition": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:24098072"
     ]
    },
    {
     "study_id": "STU-0d6e81a799d70710",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34507719"
     ]
    },
    {
     "study_id": "STU-22c1ad34f81a696e",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2014,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cardiovascular": "BENEFIT",
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:24816553"
     ]
    },
    {
     "study_id": "STU-3dc116fcfd57c55a",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2013,
     "dose": "4 g",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": []
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-5ad6060176974f",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.0321",
     "original_representation": "p = 0.0321",
     "original_unit": null,
     "normalized_value": 0.0321,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:24816553"
    },
    {
     "observation_id": "QOB-1caf133483b4e0",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "4",
     "original_representation": "4 g",
     "original_unit": "g",
     "normalized_value": 4000.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNIT_CONVERSION",
     "record_id": "oax:https://openalex.org/W1974660368"
    }
   ],
   "opposition": {
    "considered": 24,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-14e350e548aa66",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 18
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-05d71ddf0224651f",
     "STU-0d6e81a799d70710",
     "STU-22c1ad34f81a696e",
     "STU-3dc116fcfd57c55a",
     "STU-7a6802447f3bccd1",
     "STU-8b7a264767a5af44",
     "STU-8f9592a9dd078693",
     "STU-a7cf9f8793ae0e14",
     "STU-a9f054c832bc2633",
     "STU-b9fab9f8eeb29525",
     "STU-ba75ddbe7e652526",
     "STU-bc86b22b74809c90",
     "STU-cb34ecd303ff2b4b",
     "STU-d22aca311fbb5977",
     "STU-e14bdb1389459d41",
     "STU-e5d02adfbb0bc12b",
     "STU-e6bfb66eec4a5913",
     "STU-f5a10c8daa564e89"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-0fcadb3351bb0b8d",
   "object": "krill oil constituents",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "META_ANALYSIS",
    "RCT",
    "TRIAL"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "250 mg/kg; 4 g; 500 mg",
   "duration": "24 weeks; 28 day; 8 weeks; 90 days",
   "grade_basis": {
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 20,
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-0d6e81a799d70710",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "glucose": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34507719"
     ]
    },
    {
     "study_id": "STU-2c53d6cbf86978dd",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": "24 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "inflammation": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": []
    },
    {
     "study_id": "STU-2cacbac4b076f9c0",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "gastrointestinal": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:42348265"
     ]
    },
    {
     "study_id": "STU-42b8285bbade0189",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cognition": "BENEFIT",
      "exercise": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34573047"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-4f2cf83298591d",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "24 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W3128468041"
    },
    {
     "observation_id": "QOB-abc37f84e766b2",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "reduced (by 68%",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "oax:https://openalex.org/W3128468041"
    }
   ],
   "opposition": {
    "considered": 31,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-4d3d82f5726457",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 20
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-0d6e81a799d70710",
     "STU-2c53d6cbf86978dd",
     "STU-2cacbac4b076f9c0",
     "STU-42b8285bbade0189",
     "STU-53e958040237b040",
     "STU-923c0fd79b21c788",
     "STU-96becdc7a0436e1a",
     "STU-a12d9a8c0bb05ab1",
     "STU-a536ab1a8047a3e0",
     "STU-a9f054c832bc2633",
     "STU-b88d665833f6a4da",
     "STU-bc86b22b74809c90",
     "STU-be73f0e5289d1db7",
     "STU-bf3371ee8d0ac7a1",
     "STU-cf36744f05e3e5cf",
     "STU-d3c1ab5c3fed4032",
     "STU-d95dae055346ddb8",
     "STU-e14bdb1389459d41",
     "STU-eaa756529e9cc2fe",
     "STU-fe515788dea7b530"
    ],
    "observations_pooled": 0
   }
  }
 ]
}