{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Kratom",
 "slug": "kratom",
 "dataset_id": "MFI-KRATOM-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "1b64cf4022aba55d",
 "claims": [
  {
   "claim_id": "CLM-153aaa97eb6da220",
   "object": "kratom",
   "outcome": "mood",
   "direction": "HARM",
   "grade": "VERY_LOW",
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    "ANIMAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 5,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 2,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
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     "design": "UNSPECIFIED",
     "model": "HUMAN",
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     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "HARM",
      "mood": "HARM"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:40823326"
     ]
    },
    {
     "study_id": "STU-bee858edbe955dea",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "HARM"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:39640144"
     ]
    },
    {
     "study_id": "STU-c27e2b0d1aa480bd",
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     "model": "ANIMAL",
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     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41106041"
     ]
    },
    {
     "study_id": "STU-cc7bbaad1e6e2bf9",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "HARM"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:42144893"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-712e25408896a8",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 116,
     "original_representation": "116",
     "original_unit": null,
     "normalized_value": 116.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:42144893"
    },
    {
     "observation_id": "QOB-af6120366701d1",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "decrease minute volume by 50%",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41106041"
    }
   ],
   "opposition": {
    "considered": 13,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-a1f69a1471a48b",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "HARM": 5
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
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     "STU-bee858edbe955dea",
     "STU-c27e2b0d1aa480bd",
     "STU-cc7bbaad1e6e2bf9",
     "STU-d6e63f80823576ca"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-4239ca40f3cbf412",
   "object": "kratom",
   "outcome": "blood pressure",
   "direction": "HARM",
   "grade": "LOW",
   "design": [
    "RCT",
    "SYSTEMATIC_REVIEW"
   ],
   "models": [
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 2,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 0,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-94c0f0ae50309c0f",
     "design": "SYSTEMATIC_REVIEW",
     "model": "IN_VITRO",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "HARM",
      "cardiovascular": "HARM",
      "cognition": "HARM",
      "mortality": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34646135"
     ]
    },
    {
     "study_id": "STU-df4e4bbd997c1c0d",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "HARM",
      "exercise": "HARM",
      "kidney": "HARM",
      "liver": "HARM"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:39807458"
     ]
    }
   ],
   "quantitative_observations": [],
   "opposition": {
    "considered": 2,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-e49b22dc121a18",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "HARM": 2
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-94c0f0ae50309c0f",
     "STU-df4e4bbd997c1c0d"
    ],
    "observations_pooled": 0
   }
  }
 ]
}