{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Kava",
 "slug": "kava",
 "dataset_id": "MFI-KAVA-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "d0f32690db86b869",
 "claims": [
  {
   "claim_id": "CLM-df115ad613727cde",
   "object": "kava",
   "outcome": "cancer",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "UNSPECIFIED",
   "duration": "7 day; 8 weeks",
   "grade_basis": {
    "bound_studies": 6,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 4,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-1af9f0539ce37702",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2020,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:31711251"
     ]
    },
    {
     "study_id": "STU-483f3e8bc0208bcc",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34368644"
     ]
    },
    {
     "study_id": "STU-822f7e125088fc56",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2020,
     "dose": null,
     "duration": "7 day",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "mood": "HARM",
      "mortality": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:32102948"
     ]
    },
    {
     "study_id": "STU-d7255549d880267e",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2011,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "liver": "HARM",
      "weight": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:21871523"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-3e7da8b2a4068b",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "7 day",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:32102948"
    },
    {
     "observation_id": "QOB-8e641b8e75de31",
     "observation_kind": "effect",
     "effect_measure": "percent change",
     "original_value": "47",
     "original_representation": "reduced lung tumor multiplicity by 47%",
     "original_unit": null,
     "normalized_value": 47.0,
     "normalized_unit": null,
     "endpoint": "cancer",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:19138990"
    },
    {
     "observation_id": "QOB-9bbe664cd21cbc",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "8 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:19138990"
    },
    {
     "observation_id": "QOB-b3d898979fdbd6",
     "observation_kind": "effect",
     "effect_measure": "percent change",
     "original_value": "54.5",
     "original_representation": "reduction of genitourinary weight (a surrogate of tumor burden) by 54.5%",
     "original_unit": null,
     "normalized_value": 54.5,
     "normalized_unit": null,
     "endpoint": "cancer",
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:34368644"
    }
   ],
   "opposition": {
    "considered": 12,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-6e7ae1d354f6f0",
    "synthesis_outcome": "PARTIAL_SYNTHESIS",
    "direction_tally": {
     "BENEFIT": 6
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-1af9f0539ce37702",
     "STU-483f3e8bc0208bcc",
     "STU-822f7e125088fc56",
     "STU-d7255549d880267e",
     "STU-e8cbe9f6b5784e3d",
     "STU-f68ee90ceaf2294e"
    ],
    "observations_pooled": 2
   }
  },
  {
   "claim_id": "CLM-bed2595342f62e20",
   "object": "kava constituents",
   "outcome": "mood",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "META_ANALYSIS",
    "RCT",
    "TRIAL"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "300 mg; 40 mg/kg",
   "duration": "21 days",
   "grade_basis": {
    "bound_studies": 5,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "VERY_LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 5,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-5a47603a93a7234a",
     "design": "TRIAL",
     "model": "HUMAN",
     "publication_year": 2004,
     "dose": "300 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "crf:10.1002/ptr.1422"
     ]
    },
    {
     "study_id": "STU-70591be7f1fade24",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2003,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "METADATA_ONLY",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "oax:https://openalex.org/W2005720665"
     ]
    },
    {
     "study_id": "STU-b3059e20a33e771e",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2004,
     "dose": "300 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cognition": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "crf:10.1002/hup.581"
     ]
    },
    {
     "study_id": "STU-bd93ec1dff505f37",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2022,
     "dose": "40 mg/kg",
     "duration": "21 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:35528470"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-8b06ccc711d1d6",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "40",
     "original_representation": "40 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 40.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:35528470"
    },
    {
     "observation_id": "QOB-afe0e6c8ef5c7e",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "21 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:35528470"
    },
    {
     "observation_id": "QOB-e464a2041681f7",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 50,
     "original_representation": "50",
     "original_unit": null,
     "normalized_value": 50.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.1002/ptr.1422"
    },
    {
     "observation_id": "QOB-f517213687c773",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "300",
     "original_representation": "300 mg",
     "original_unit": "mg",
     "normalized_value": 300.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "crf:10.1002/ptr.1422"
    },
    {
     "observation_id": "QOB-f65f61533503df",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "300",
     "original_representation": "300 mg",
     "original_unit": "mg",
     "normalized_value": 300.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "crf:10.1002/hup.581"
    }
   ],
   "opposition": {
    "considered": 14,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-ccdc15f12df4ef",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 5
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-5a47603a93a7234a",
     "STU-70591be7f1fade24",
     "STU-b3059e20a33e771e",
     "STU-bd93ec1dff505f37",
     "STU-bfcaa32dec40d144"
    ],
    "observations_pooled": 0
   }
  }
 ]
}