{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Guayusa",
 "slug": "guayusa",
 "dataset_id": "MFI-GUAYUS-20261022-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "5a60be3ff12d724a",
 "claims": [
  {
   "claim_id": "CLM-2452185f7ece0b1e",
   "object": "guayusa constituents",
   "outcome": "blood pressure",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "RCT"
   ],
   "models": [
    "HUMAN"
   ],
   "dose": "650 mg",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 1,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 3,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "SOME_CONCERNS"
   },
   "bound_studies": [
    {
     "study_id": "STU-237da627f66bf535",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2023,
     "dose": "650 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "blood pressure": "BENEFIT",
      "cognition": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "crf:10.3390/nu15245018"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-21019212a19b54",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p ≤ 0.05 | p ≤ 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.3390/nu15245018"
    },
    {
     "observation_id": "QOB-d5cce03f33d85a",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "650",
     "original_representation": "650 mg",
     "original_unit": "mg",
     "normalized_value": 650.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "crf:10.3390/nu15245018"
    },
    {
     "observation_id": "QOB-e4bb230e273030",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p ≤ 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.3390/nu15245018"
    }
   ],
   "opposition": {
    "considered": 2,
    "bound": 1
   },
   "synthesis": {
    "synthesis_id": "SYN-8f1ab051ba2a89",
    "synthesis_outcome": "SYNTHESIS_INAPPROPRIATE",
    "direction_tally": {
     "BENEFIT": 1
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-237da627f66bf535"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-333e0ec53613495d",
   "object": "guayusa constituents",
   "outcome": "mood",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "RCT"
   ],
   "models": [
    "HUMAN"
   ],
   "dose": "650 mg",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 1,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 3,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "SOME_CONCERNS"
   },
   "bound_studies": [
    {
     "study_id": "STU-237da627f66bf535",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2023,
     "dose": "650 mg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "blood pressure": "BENEFIT",
      "cognition": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "crf:10.3390/nu15245018"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-21019212a19b54",
     "observation_kind": "effect",
     "effect_measure": null,
     "original_value": null,
     "original_representation": "p ≤ 0.05 | p ≤ 0.05",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "crf:10.3390/nu15245018"
    },
    {
     "observation_id": "QOB-d5cce03f33d85a",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "650",
     "original_representation": "650 mg",
     "original_unit": "mg",
     "normalized_value": 650.0,
     "normalized_unit": "mg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "crf:10.3390/nu15245018"
    },
    {
     "observation_id": "QOB-e4bb230e273030",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.05",
     "original_representation": "p ≤ 0.05",
     "original_unit": null,
     "normalized_value": 0.05,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "crf:10.3390/nu15245018"
    }
   ],
   "opposition": {
    "considered": 3,
    "bound": 2
   },
   "synthesis": {
    "synthesis_id": "SYN-dafa6e3540c1d0",
    "synthesis_outcome": "SYNTHESIS_INAPPROPRIATE",
    "direction_tally": {
     "BENEFIT": 1
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-237da627f66bf535"
    ],
    "observations_pooled": 0
   }
  }
 ]
}