{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Coffee",
 "slug": "coffee",
 "dataset_id": "MFI-COFFEE-20261013-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "cbb4d2e6e1ec5391",
 "claims": [
  {
   "claim_id": "CLM-b378cb19aa95fcde",
   "object": "coffee",
   "outcome": "weight",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "COHORT",
    "CROSS_SECTIONAL",
    "IN_VITRO",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "0.4 mg/kg; 400 mg/kg; 5 g; 592.0 g",
   "duration": "12 weeks; 4 weeks; 9 weeks",
   "grade_basis": {
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 15,
    "rob_worst_judgment": "SOME_CONCERNS"
   },
   "bound_studies": [
    {
     "study_id": "STU-0f49702106f9819a",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": "12 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:39275165"
     ]
    },
    {
     "study_id": "STU-3a074f54b3bae036",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2020,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "ABSTRACT_ONLY",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cognition": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": []
    },
    {
     "study_id": "STU-4ae02e0180f19a55",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "BENEFIT",
      "inflammation": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:40931582"
     ]
    },
    {
     "study_id": "STU-579621d2c9c7ce28",
     "design": "CROSS_SECTIONAL",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "glucose": "HARM",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41971704"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-991436379f4c0d",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 38,
     "original_representation": "38",
     "original_unit": null,
     "normalized_value": 38.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:39275165"
    },
    {
     "observation_id": "QOB-ce286668f34b97",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:39275165"
    },
    {
     "observation_id": "QOB-28863e324b55d7",
     "observation_kind": "p_value",
     "effect_measure": "p-value",
     "original_value": "0.001",
     "original_representation": "p < 0.001",
     "original_unit": null,
     "normalized_value": 0.001,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40931582"
    },
    {
     "observation_id": "QOB-3c5ca374484805",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 980,
     "original_representation": "980",
     "original_unit": null,
     "normalized_value": 980.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40931582"
    },
    {
     "observation_id": "QOB-ec420aa2d780b1",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 6311,
     "original_representation": "6311",
     "original_unit": null,
     "normalized_value": 6311.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:41971704"
    }
   ],
   "opposition": {
    "considered": 43,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-dc4320d92d6995",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 15
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-0f49702106f9819a",
     "STU-3a074f54b3bae036",
     "STU-4ae02e0180f19a55",
     "STU-579621d2c9c7ce28",
     "STU-58293b7e4ebd6d88",
     "STU-72d84f027f2aa7b8",
     "STU-85663ed6a8311451",
     "STU-90619d521412a7fe",
     "STU-924f3ef329470402",
     "STU-9e8e3baff2fde901",
     "STU-9f2f1431aa93cf77",
     "STU-cea669b7fbf2ec8a",
     "STU-df729279c796164a",
     "STU-e0d09b443627340a",
     "STU-eab2b4ee604b7eb4"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-1db7cf815992f79d",
   "object": "coffee",
   "outcome": "cholesterol",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "CROSS_SECTIONAL",
    "IN_VITRO",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "200 mg/kg; 400 mg/kg; 5 g",
   "duration": "12 month; 4 weeks; 9 weeks",
   "grade_basis": {
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 11,
    "rob_worst_judgment": "NOT_ASSESSABLE"
   },
   "bound_studies": [
    {
     "study_id": "STU-29cc231496ded869",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cancer": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cholesterol": "BENEFIT"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:41531586"
     ]
    },
    {
     "study_id": "STU-34d2e76fc113af68",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "HARM",
      "cancer": "UNCERTAIN",
      "cardiovascular": "HARM"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:38571923"
     ]
    },
    {
     "study_id": "STU-5822d9fdba520568",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": "12 month",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "HARM",
      "cardiovascular": "HARM",
      "cholesterol": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:40868130"
     ]
    },
    {
     "study_id": "STU-85663ed6a8311451",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": "400 mg/kg",
     "duration": "4 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cholesterol": "BENEFIT",
      "exercise": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:41509709"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-01e2a4879b1972",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 40,
     "original_representation": "40",
     "original_unit": null,
     "normalized_value": 40.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:40868130"
    },
    {
     "observation_id": "QOB-29fb419a94a372",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "12 month",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:40868130"
    },
    {
     "observation_id": "QOB-052614954386a0",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "400",
     "original_representation": "400 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 400.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:41509709"
    },
    {
     "observation_id": "QOB-f9d14f6598f0b4",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "4 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41509709"
    }
   ],
   "opposition": {
    "considered": 27,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-3bdad7379dd5f6",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 11
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-29cc231496ded869",
     "STU-34d2e76fc113af68",
     "STU-5822d9fdba520568",
     "STU-85663ed6a8311451",
     "STU-924f3ef329470402",
     "STU-9a9e87e7bdac422c",
     "STU-abaf47abfe126cba",
     "STU-bc12a4bf52ff38c2",
     "STU-c4d0235b92cd48f1",
     "STU-df52f817a6a70b83",
     "STU-e11b6a52855b70d0"
    ],
    "observations_pooled": 0
   }
  }
 ]
}