{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Black Seed",
 "slug": "black-seed",
 "dataset_id": "MFI-BLACKS-20261013-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "f49fabc773121120",
 "claims": [
  {
   "claim_id": "CLM-9f84686c9a712c18",
   "object": "black seed (nigella sativa) constituents",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "10 mg/kg; 150 mg/kg; 200 mg; 40 g/kg; 50 mg/kg",
   "duration": "12 days; 14 days; 21 days; 24 days; 28 days; 49 day; 8 weeks; 90 days",
   "grade_basis": {
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 22,
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-01d774d57b01ff85",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": "21 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34355083"
     ]
    },
    {
     "study_id": "STU-01ded4814946e82e",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2018,
     "dose": "10 mg/kg",
     "duration": "8 weeks",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "kidney": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:29854586"
     ]
    },
    {
     "study_id": "STU-06aa293ba6247163",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": "150 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "immune": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:42529485"
     ]
    },
    {
     "study_id": "STU-120e43f28e249e4d",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": "200 mg",
     "duration": "90 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "inflammation": "BENEFIT",
      "skin": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41575220"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-5cc48797370577",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "21 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:34355083"
    },
    {
     "observation_id": "QOB-aea89318bed4bf",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 6,
     "original_representation": "6",
     "original_unit": null,
     "normalized_value": 6.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:29854586"
    },
    {
     "observation_id": "QOB-e1a0c127732ed4",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "10",
     "original_representation": "10 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 10.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:29854586"
    },
    {
     "observation_id": "QOB-fc2fa70d8a0a2e",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "8 weeks",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:29854586"
    },
    {
     "observation_id": "QOB-4625c11655e3ab",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "150",
     "original_representation": "150 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 150.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42529485"
    },
    {
     "observation_id": "QOB-4326c4a2f09cd8",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "90 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41575220"
    }
   ],
   "opposition": {
    "considered": 47,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-a9d1a7c6befc2c",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 22
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-01d774d57b01ff85",
     "STU-01ded4814946e82e",
     "STU-06aa293ba6247163",
     "STU-120e43f28e249e4d",
     "STU-2ddaac2c290b8f10",
     "STU-2eb4a36aa1ce1c8f",
     "STU-37d56db87dab616b",
     "STU-37e5f87e8013b98c",
     "STU-453cfad5b50b417b",
     "STU-4802c9d0addfab6f",
     "STU-4b9c6edcb8fee0ee",
     "STU-60fef41383a62bff",
     "STU-66a69f51e8e81ef2",
     "STU-80f409e17acafd80",
     "STU-83311db30e4faced",
     "STU-96e8850b5328ac94",
     "STU-a8d08c677a2ddc96",
     "STU-c3deb3dee549ce4f",
     "STU-e0cfe8cc9c6d67ef",
     "STU-ef4278ec2808f6da",
     "STU-f778ca9e67af4b21",
     "STU-fd7c085b5d78fe76"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-fe4f1d56f7a03b9c",
   "object": "black seed (nigella sativa) constituents",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "IN_VITRO",
    "RCT"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "10 mg/kg; 100 mg/kg; 150 mg/kg; 200 mg; 200 mg/kg; 5 mg/kg",
   "duration": "12 weeks; 14 days; 21 day; 21 days; 25 days; 28 days; 90 days",
   "grade_basis": {
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "confidence_cap": "VERY_LOW",
    "rob_cap": "MODERATE",
    "consistency_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "bound_studies": 19,
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-01d774d57b01ff85",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2021,
     "dose": null,
     "duration": "21 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:34355083"
     ]
    },
    {
     "study_id": "STU-02a0a134643dae3d",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "UNCERTAIN",
      "gastrointestinal": "UNCERTAIN",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:40129997"
     ]
    },
    {
     "study_id": "STU-06aa293ba6247163",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2026,
     "dose": "150 mg/kg",
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cholesterol": "BENEFIT",
      "immune": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:42529485"
     ]
    },
    {
     "study_id": "STU-0b21ef42baae0be9",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "gastrointestinal": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:42653115"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-5cc48797370577",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "21 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:34355083"
    },
    {
     "observation_id": "QOB-4625c11655e3ab",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "150",
     "original_representation": "150 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 150.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42529485"
    }
   ],
   "opposition": {
    "considered": 42,
    "bound": 0
   },
   "synthesis": {
    "synthesis_id": "SYN-4c93cd6fbbb706",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 19
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-01d774d57b01ff85",
     "STU-02a0a134643dae3d",
     "STU-06aa293ba6247163",
     "STU-0b21ef42baae0be9",
     "STU-120e43f28e249e4d",
     "STU-453cfad5b50b417b",
     "STU-4802c9d0addfab6f",
     "STU-4b9c6edcb8fee0ee",
     "STU-66a69f51e8e81ef2",
     "STU-77e9dc3de7a4eae4",
     "STU-7d7a728f424299b3",
     "STU-83311db30e4faced",
     "STU-850f82c2a8543f74",
     "STU-8a3caec52fdf42b5",
     "STU-8b61e96ae3a80c5d",
     "STU-96e8850b5328ac94",
     "STU-ae6cb4c9138c1019",
     "STU-f56d2c7d87623251",
     "STU-fd7c085b5d78fe76"
    ],
    "observations_pooled": 0
   }
  }
 ]
}