{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Berberine",
 "slug": "berberine",
 "dataset_id": "MFI-BERBER-20261019-FS",
 "engine_version": "2.1.0",
 "package_sha256_prefix": "fa2352b4b1a214fb",
 "claims": [
  {
   "claim_id": "CLM-35ff2785f3a6f0a9",
   "object": "berberine",
   "outcome": "inflammation",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "COHORT",
    "IN_VITRO",
    "SYSTEMATIC_REVIEW"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "1.24 mg/kg; 100 mg/kg; 200 mg/kg; 30 mg/kg",
   "duration": "14 days; 2 months; 7 days",
   "grade_basis": {
    "bound_studies": 13,
    "confidence_cap": "VERY_LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "HIGH",
    "directness_cap": "LOW",
    "extraction_cap": "LOW",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 11,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-01137ffb4f7c9124",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "cognition": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT",
      "mood": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41164411"
     ]
    },
    {
     "study_id": "STU-21eead42ccd5f76e",
     "design": "COHORT",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": "2 months",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:38674895"
     ]
    },
    {
     "study_id": "STU-98036494788b6d9d",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": "1.24 mg/kg",
     "duration": "14 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41327335"
     ]
    },
    {
     "study_id": "STU-9ae1a9be0f547de1",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cholesterol": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41292240"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-2269b5d6a593c6",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "7 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:42262730"
    },
    {
     "observation_id": "QOB-367fdeddd6bab3",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "200",
     "original_representation": "200 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 200.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42262730"
    },
    {
     "observation_id": "QOB-401bbda85286d0",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "1.24",
     "original_representation": "1.24 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 1.24,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:41327335"
    },
    {
     "observation_id": "QOB-609668a1c5a266",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "2 months",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:38674895"
    },
    {
     "observation_id": "QOB-64ddc3736b47da",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "30",
     "original_representation": "30 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 30.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42792239"
    }
   ],
   "opposition": {
    "considered": 16,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-9f3940b21d3285",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 13
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-01137ffb4f7c9124",
     "STU-21eead42ccd5f76e",
     "STU-98036494788b6d9d",
     "STU-9ae1a9be0f547de1",
     "STU-b475912a695a7eaf",
     "STU-b5fbd009d7207783",
     "STU-ba72bbe291658f29",
     "STU-cacd77a95d77920a",
     "STU-dc346a9fd3f9fa57",
     "STU-dd72a27fb9096c92",
     "STU-ddfe343ee277274f",
     "STU-e89138f1626eae12",
     "STU-ea43351fcad73257"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-0af36a7b7e6edeb4",
   "object": "berberine",
   "outcome": "antioxidant",
   "direction": "BENEFIT",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "COHORT",
    "IN_VITRO"
   ],
   "models": [
    "ANIMAL",
    "HUMAN",
    "IN_VITRO"
   ],
   "dose": "1.24 mg/kg; 100 mg/kg; 200 mg/kg; 30 mg/kg",
   "duration": "14 days; 7 days",
   "grade_basis": {
    "bound_studies": 8,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "LOW",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 7,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-040d6f2e06fdf2fe",
     "design": "COHORT",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:41745094"
     ]
    },
    {
     "study_id": "STU-32a24e7927c9cb48",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "glucose": "BENEFIT",
      "liver": "BENEFIT",
      "weight": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41488874"
     ]
    },
    {
     "study_id": "STU-98036494788b6d9d",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": "1.24 mg/kg",
     "duration": "14 days",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "immune": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41327335"
     ]
    },
    {
     "study_id": "STU-9ae1a9be0f547de1",
     "design": "IN_VITRO",
     "model": "IN_VITRO",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "antioxidant": "BENEFIT",
      "cancer": "BENEFIT",
      "cardiovascular": "BENEFIT",
      "cholesterol": "BENEFIT",
      "inflammation": "BENEFIT"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41292240"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-2269b5d6a593c6",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "7 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:42262730"
    },
    {
     "observation_id": "QOB-367fdeddd6bab3",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "200",
     "original_representation": "200 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 200.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42262730"
    },
    {
     "observation_id": "QOB-401bbda85286d0",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "1.24",
     "original_representation": "1.24 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 1.24,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:41327335"
    },
    {
     "observation_id": "QOB-64ddc3736b47da",
     "observation_kind": "dose",
     "effect_measure": "dose",
     "original_value": "30",
     "original_representation": "30 mg/kg",
     "original_unit": "mg/kg",
     "normalized_value": 30.0,
     "normalized_unit": "mg/kg",
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "UNNORMALIZED",
     "record_id": "epmc:42792239"
    },
    {
     "observation_id": "QOB-6d71fa56ba9a24",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "14 days",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41327335"
    }
   ],
   "opposition": {
    "considered": 12,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-ee8971eaf3d0f8",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "BENEFIT": 8
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-040d6f2e06fdf2fe",
     "STU-32a24e7927c9cb48",
     "STU-98036494788b6d9d",
     "STU-9ae1a9be0f547de1",
     "STU-b475912a695a7eaf",
     "STU-ba72bbe291658f29",
     "STU-dd72a27fb9096c92",
     "STU-ea43351fcad73257"
    ],
    "observations_pooled": 0
   }
  }
 ]
}