{
 "artifact_type": "BOUNDED_EVIDENCE_PREVIEW",
 "preview_boundary": "Deliberately bounded representative records for demonstration. Not a complete claim, evidence, study, or provenance inventory.",
 "food": "Activated Charcoal",
 "slug": "activated-charcoal",
 "dataset_id": "MFI-ACTCHA-20261023-FS",
 "engine_version": "2.0-R13",
 "package_sha256_prefix": "bcb39ac03760fc2f",
 "claims": [
  {
   "claim_id": "CLM-50d28a5780c8f0e0",
   "object": "activated charcoal",
   "outcome": "mortality",
   "direction": "NULL",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "RCT",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "UNSPECIFIED",
   "duration": "6 year",
   "grade_basis": {
    "bound_studies": 3,
    "confidence_cap": "LOW",
    "consistency_cap": "MODERATE",
    "design_ceiling": "MODERATE",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "REJECTED_ONLY",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "downgraded_one_step_for_bound_opposition",
    "quantitative_observations": 2,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-08767454fc59e548",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "UNCERTAIN",
      "cardiovascular": "UNCERTAIN",
      "gastrointestinal": "UNCERTAIN",
      "mortality": "UNCERTAIN"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:41333520"
     ]
    },
    {
     "study_id": "STU-c69b6eb769af277e",
     "design": "RCT",
     "model": "HUMAN",
     "publication_year": 2025,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "UNCERTAIN",
      "mortality": "UNCERTAIN"
     },
     "risk_of_bias": "SOME_CONCERNS",
     "provenance_refs": [
      "epmc:40131706"
     ]
    },
    {
     "study_id": "STU-e628a5787ff077ff",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2025,
     "dose": null,
     "duration": "6 year",
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "inflammation": "UNCERTAIN",
      "mortality": "UNCERTAIN"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:41142969"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-1718ddeb3aaab9",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 10,
     "original_representation": "10",
     "original_unit": null,
     "normalized_value": 10.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:41333520"
    },
    {
     "observation_id": "QOB-83de9c3165d850",
     "observation_kind": "duration",
     "effect_measure": "duration",
     "original_value": null,
     "original_representation": "6 year",
     "original_unit": null,
     "normalized_value": null,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "FAILED_EXTRACTION",
     "validation_state": "FAILED_VALIDATION",
     "transformation": "NONE",
     "record_id": "epmc:41142969"
    }
   ],
   "opposition": {
    "considered": 3,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-4077aeaad02951",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "UNCERTAIN": 3
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-08767454fc59e548",
     "STU-c69b6eb769af277e",
     "STU-e628a5787ff077ff"
    ],
    "observations_pooled": 0
   }
  },
  {
   "claim_id": "CLM-f0993ca40a848561",
   "object": "activated charcoal",
   "outcome": "gastrointestinal",
   "direction": "HARM",
   "grade": "VERY_LOW",
   "design": [
    "ANIMAL",
    "UNSPECIFIED"
   ],
   "models": [
    "ANIMAL",
    "HUMAN"
   ],
   "dose": "UNSPECIFIED",
   "duration": "UNSPECIFIED",
   "grade_basis": {
    "bound_studies": 3,
    "confidence_cap": "LOW",
    "consistency_cap": "HIGH",
    "design_ceiling": "VERY_LOW",
    "directness_cap": "LOW",
    "extraction_cap": "MODERATE",
    "numeric_cap": "MODERATE",
    "numeric_states": [
     "NO_NUMERICS_PRESENT",
     "VALIDATED_EXTRACTION"
    ],
    "opposition_adj": "none",
    "quantitative_observations": 1,
    "rob_cap": "MODERATE",
    "rob_worst_judgment": "INSUFFICIENT_INFORMATION"
   },
   "bound_studies": [
    {
     "study_id": "STU-2202d31da1b34a81",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2017,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:28571191"
     ]
    },
    {
     "study_id": "STU-9cf6f20801c0afe1",
     "design": "ANIMAL",
     "model": "ANIMAL",
     "publication_year": 2024,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "blood pressure": "HARM",
      "gastrointestinal": "HARM"
     },
     "risk_of_bias": "INSUFFICIENT_INFORMATION",
     "provenance_refs": [
      "epmc:38410740"
     ]
    },
    {
     "study_id": "STU-a4b67734c53d705c",
     "design": "UNSPECIFIED",
     "model": "HUMAN",
     "publication_year": 2026,
     "dose": null,
     "duration": null,
     "extraction_status": "UNASSESSED",
     "full_text_status": "FULL_TEXT",
     "endpoint_directions": {
      "gastrointestinal": "HARM"
     },
     "risk_of_bias": "NOT_ASSESSABLE",
     "provenance_refs": [
      "epmc:PPR1323113"
     ]
    }
   ],
   "quantitative_observations": [
    {
     "observation_id": "QOB-069942c1f49708",
     "observation_kind": "n",
     "effect_measure": "sample size",
     "original_value": 173,
     "original_representation": "173",
     "original_unit": null,
     "normalized_value": 173.0,
     "normalized_unit": null,
     "endpoint": null,
     "extraction_state": "VALIDATED",
     "validation_state": "VALID",
     "transformation": "IDENTITY",
     "record_id": "epmc:PPR1323113"
    }
   ],
   "opposition": {
    "considered": 12,
    "bound": 3
   },
   "synthesis": {
    "synthesis_id": "SYN-ba3d51b231c7b8",
    "synthesis_outcome": "QUALITATIVE_ONLY",
    "direction_tally": {
     "HARM": 3
    },
    "directional_disagreement": false,
    "heterogeneity": "not_assessed_quantitatively",
    "study_members": [
     "STU-2202d31da1b34a81",
     "STU-9cf6f20801c0afe1",
     "STU-a4b67734c53d705c"
    ],
    "observations_pooled": 0
   }
  }
 ]
}